We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
Read More
9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
Omega-3s improve cholesterol parameters
Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats.
We examined how swapping a saturated fat diet for omega-3 polyunsaturated fatty acids (n-3PUFAs) affects cholesterol and bone health in hypercholesterolemic rats.
In our study, rats that shifted to an n-3PUFA diet saw a notable decrease in serum lipids. While the diet appeared to positively impact their bone loss linked to periodontitis, rats on the n-3PUFA diet showed results similar to those on a commercial diet, indicating no major advantage of fish oil over a balanced diet.
Overall, our findings suggest that while omega-3s can help with cholesterol, they don't offer significant improvements over typical diets in these conditions.
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Most Useful Reviews
9
High-quality ingredients
3 people found this helpful
The ingredients are of high quality and suitable for adults. Without fish oil and with a pleasant taste, the package lasts for three months. I've seen excellent results in my blood tests, with improved HDL cholesterol and reduced LDL cholesterol levels. I was just about to reorder, but unfortunately, it’s not available at the moment.
Read More
7.5
Visible improvement
4 people found this helpful
I noticed visible changes in my skin within a week of taking a high dose of 6 softgels daily. My skin became smoother and pores finer. Studies suggest that a higher omega-3 intake may help prevent brain shrinkage with age. I found that one softgel daily was ineffective; at least three per day, one with each meal, is necessary for it to work well, particularly in managing high cholesterol.
Read More
7.5
Helps in cold weather
2 people found this helpful
I take this before the cold weather as it helps me adapt and prevents me from feeling too cold. This vegan formula was recommended by my doctor for its superior absorption. It has also helped with my high cholesterol levels.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
Read More
9
CA-rich fish oils lower cholesterol
Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis.
We investigated whether cetoleic acid (CA), a healthy fat found in certain fish, can help lower cholesterol levels in rodents. Our systematic review included 12 studies, assessing how CA-rich fish oils influenced total cholesterol compared to regular diets.
The results showed a significant reduction in cholesterol levels in rodents that consumed CA-rich oils. However, it’s important to note that the risk of bias in the studies varied, making our conclusions tentative. Overall, these findings suggest CA-rich fish oils could play a beneficial role in heart health, but further research in humans is needed.
Read More
9
Scallop oil significantly reduces cholesterol
Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice.
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
Omega-3 effective for heart risk
The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
We examined the role of eicosapentaenoic acid (EPA), specifically icosapent ethyl, in reducing cardiovascular disease risks. Approved by the FDA, this omega-3 treatment showed a notable 25% reduction in major heart events for high-risk patients. These patients already had controlled cholesterol but elevated triglyceride levels.
Importantly, while EPA proved effective, mixed omega-3 products lacking substantial evidence for heart health did not provide the same benefits. We believe adding EPA-only formulations to cardiovascular prevention guidelines is essential for at-risk individuals.
Read More
9
8-HEPE benefits cholesterol management
8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice.
We explored how 8-hydroxyeicosapentaenoic acid (8-HEPE), derived from Pacific krill, could improve cholesterol levels in mice commonly used for dyslipidemia studies.
Over eighteen weeks, mice on a high-cholesterol diet receiving 8-HEPE showed significantly higher levels of good HDL cholesterol, alongside lower levels of bad LDL cholesterol and liver triglycerides.
This suggests that 8-HEPE may enhance lipid profiles and liver health by influencing certain genes in macrophages. While promising, further research is needed to confirm these benefits in humans.
The ingredients are of high quality and suitable for adults. Without fish oil and with a pleasant taste, the package lasts for three months. I've seen excellent results in my blood tests, with improved HDL cholesterol and reduced LDL cholesterol levels. I was just about to reorder, but unfortunately, it’s not available at the moment.
Read More
7.5
Visible improvement
4 people found this helpful
I noticed visible changes in my skin within a week of taking a high dose of 6 softgels daily. My skin became smoother and pores finer. Studies suggest that a higher omega-3 intake may help prevent brain shrinkage with age. I found that one softgel daily was ineffective; at least three per day, one with each meal, is necessary for it to work well, particularly in managing high cholesterol.
Read More
7.5
Helps in cold weather
2 people found this helpful
I take this before the cold weather as it helps me adapt and prevents me from feeling too cold. This vegan formula was recommended by my doctor for its superior absorption. It has also helped with my high cholesterol levels.
Read More
7.5
Boosts general health
The quality is excellent, and the omega-3 is vegan. The packaging lasts for three months with a pill a day, or two for a more potent effect. It enhances vitamin D effectiveness and benefits skin, hair, heart health, and cholesterol. It also aids in reducing inflammation without a fishy taste.
Read More
6
No nasty ingredients
I appreciate this vegan, non-fish omega-3 source. It helps improve heart health, reduces inflammation, and lowers cholesterol levels. I prefer products without unpleasant ingredients like silicon dioxide and magnesium stearate; this is a quality product.
Read More
Frequently Asked Questions
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has been widely discussed for its potential benefits in managing cardiovascular health, including high cholesterol. Research indicates that omega-3 fatty acids, particularly EPA and DHA found in fish oil, can help lower triglyceride levels—a type of fat in the blood that contributes to high cholesterol. In some cases, these fatty acids may also raise levels of HDL (high-density lipoprotein), often referred to as "good" cholesterol. However, while omega-3s can be a beneficial part of a heart-healthy diet, they are not a stand-alone solution for cholesterol management.
It's essential to understand that fish oil supplementation should not replace standard cholesterol-lowering medications or lifestyle changes like diet and exercise. Consult with a healthcare professional before adding omega-3 supplements to your regimen, especially if you have existing health conditions or are taking other medications. Keeping a balanced diet rich in omega-3s from sources like fatty fish, flaxseeds, and walnuts can also support overall health and align with cholesterol management goals.
Based on user reviews, the timeline for seeing results from taking supplements for high cholesterol can vary. Many users reported significant improvements in their cholesterol levels in a matter of weeks. For instance, one user mentioned experiencing excellent results in their blood tests within a short period of use, specifically noting improved HDL and reduced LDL cholesterol levels Read Review. Another review suggested that a higher intake, such as three softgels daily instead of just one, is more effective for managing cholesterol levels, indicating that users might need to adjust their dosage for optimal results Read Review.
In summary, while individual responses may vary, many users typically start to see positive changes in their cholesterol levels within a few weeks of consistent use. Users generally emphasize the importance of proper dosing to achieve the best results, suggesting that those using lower dosages may take longer to notice a difference Read Review.
Many supplements have been investigated for their potential in managing high cholesterol, with various studies providing supportive evidence. For example, Antarctic krill oil has shown promise in reducing cholesterol levels, particularly among obese subjects in animal studies. Research indicates that it helps improve cholesterol metabolism and decreases oxidative stress, suggesting a beneficial role in cholesterol management [1]. Similarly, omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have demonstrated significant reductions in triglycerides and improvements in cholesterol profiles, particularly HDL cholesterol, essential for heart health [25][23].
Additionally, other studies have found that fish oil can lead to lower liver cholesterol and triglyceride levels compared to traditional oils [2]. However, it’s important to note that while many of these findings are compelling, they often stem from animal studies or trials with varying patient populations, meaning further research, particularly in human trials, is essential. Overall, while supplements like krill oil and omega-3s from fish and algae show potential in supporting cholesterol management, robust, conclusive evidence is still needed to fully endorse their effectiveness for high cholesterol in humans.
Users have reported a variety of improvements in their symptoms after using a vegan omega-3 supplement. Many testimonials indicate notable enhancements in cholesterol levels, with one user experiencing excellent results in blood tests, highlighting improved HDL and reduced LDL cholesterol Read Review. Another account mentioned how consistent use led to better management of high cholesterol, emphasizing the necessity of a higher dosage for optimal effectiveness Read Review.
Additionally, some users have noted secondary benefits from the supplement, such as improvements in skin texture and appearance, indicating that the omega-3s may also support overall skin health Read Review. With further reports of enhanced heart health and reduced inflammation, many users agree that this product makes a significant positive impact on their wellness, although individual responses can vary based on dosage and overall health status Read Review.
Users have shared mixed experiences regarding the combination of this supplement with others for handling high cholesterol. Many reported that a higher dosage yields better results; for example, one user found that taking six softgels daily significantly improved not only their cholesterol levels but also their skin texture, stating that three softgels per day, ideally taken with meals, are necessary for effective management of cholesterol Read Review. Another user corroborated the importance of proper dosage, noting that their results improved markedly when they increased their intake Read Review.
Additionally, users have remarked on the supplement's benefits beyond cholesterol management. Reports highlighted improvements in heart health, reduction in inflammation, and enhancements in overall wellness, suggesting that this vegan omega-3 option might work synergistically with other supplements to bolster its effects. One user mentioned that the supplement helped with cholesterol while also enhancing vitamin D effectiveness Read Review. Overall, while individual results may vary, many users advocate for monitoring dosages and potentially combining this supplement with others for a comprehensive approach to cholesterol management.
The optimal dose of omega-3 fish oil for managing high cholesterol appears to favor higher dosages. A comprehensive trial revealed that participants taking higher doses of EPA and DHA—specifically higher than 1,800 mg per day—saw their triglycerides drop significantly. This group achieved up to a 15.78% reduction in triglycerides compared to controls [11]. Furthermore, products with concentrated forms of omega-3, such as icosapent ethyl, were shown to provide significant cardiovascular benefits, especially in individuals with high triglycerides, suggesting that targeting specific formulations can enhance efficacy against high cholesterol [12].
Combining EPA and DHA supplementation, along with lifestyle changes, can enhance lipid profiles. Findings indicated that this duo could lead to noteworthy reductions in various cholesterol-related markers. Thus, if you're looking to incorporate fish oil to manage cholesterol, aim for formulations containing high doses of these omega-3 fatty acids, often in the range of 2,000-4,000 mg per day, following a healthcare provider’s recommendation [25].
9
High-quality ingredients
3 people found this helpful
The ingredients are of high quality and suitable for adults. Without fish oil and with a pleasant taste, the package lasts for three months. I've seen excellent results in my blood tests, with improved HDL cholesterol and reduced LDL cholesterol levels. I was just about to reorder, but unfortunately, it’s not available at the moment.
7.5
Visible improvement
4 people found this helpful
I noticed visible changes in my skin within a week of taking a high dose of 6 softgels daily. My skin became smoother and pores finer. Studies suggest that a higher omega-3 intake may help prevent brain shrinkage with age. I found that one softgel daily was ineffective; at least three per day, one with each meal, is necessary for it to work well, particularly in managing high cholesterol.
7.5
Boosts general health
The quality is excellent, and the omega-3 is vegan. The packaging lasts for three months with a pill a day, or two for a more potent effect. It enhances vitamin D effectiveness and benefits skin, hair, heart health, and cholesterol. It also aids in reducing inflammation without a fishy taste.
6
No nasty ingredients
I appreciate this vegan, non-fish omega-3 source. It helps improve heart health, reduces inflammation, and lowers cholesterol levels. I prefer products without unpleasant ingredients like silicon dioxide and magnesium stearate; this is a quality product.
9
Antarctic krill oil aids cholesterol
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
8
Omega-3 reduces high cholesterol
Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study.
We assessed the effectiveness of omega-3-acid ethyl acetate, which includes docosahexaenoic acid (DHA), in managing high cholesterol, particularly focusing on patients with severe hypertriglyceridemia. In a carefully designed randomized, double-blind, placebo-controlled study, 239 participants were assigned to receive either omega-3 capsules or a placebo for 12 weeks.
Throughout the study period, we measured various cholesterol-related indicators at the start and after 4, 8, and 12 weeks. We observed significant reductions in triacylglycerols, total cholesterol, non-high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein C-III in the omega-3 group compared to the placebo. These findings suggest that the combined omega-3 treatment, which prominently features DHA, can enhance lipid profiles in patients struggling with severe hypertriglyceridemia.
However, it’s important to note that there was no significant change observed in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or the LDL-C/HDL-C ratio between the two groups. Furthermore, the safety profile was similar across both groups, indicating that omega-3 capsules are generally well-tolerated. Overall, while DHA is part of the treatment, we could not isolate its specific impact on cholesterol levels due to the study’s design, which considered the effects of the omega-3 formulation collectively.
8
DHA benefits cholesterol management
The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials.
We explored the effects of docosahexaenoic acid (DHA) on cholesterol levels, based on a systematic review of randomized controlled trials. This research focused on the potential cardiovascular benefits of DHA, particularly its impact on high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels.
According to the findings, DHA is effective in raising HDL cholesterol, which is considered protective against heart disease. In fact, DHA appears to have a greater impact, compared to its counterpart, eicosapentaenoic acid (EPA). Interestingly, while DHA may also elevate LDL cholesterol levels, it simultaneously increases the size of LDL particles, making them less harmful.
Furthermore, DHA was found to contribute to lowering heart rate and blood pressure, which are key factors for cardiovascular health. The research highlighted that both EPA and DHA positively influence platelet function and reduce oxidative stress and inflammation, further supporting heart health.
Although the results show that DHA has a series of beneficial effects, the information on its role in cholesterol management needed to be more definitive. More high-quality research is warranted to establish the comprehensive impact of DHA on cholesterol and other cardiovascular risk factors.
8
Fish oil reduces liver fat accumulation
Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice.
We investigated how fish oil (FO) affects liver fat accumulation in response to a high-cholesterol (CH) diet using KK mice. The study included groups that received either safflower oil or varying amounts of fish oil along with cholesterol over eight weeks.
The results showed that the group with the highest fish oil intake had significantly lower liver triglyceride and cholesterol levels compared to the group with only safflower oil. This suggests that fish oil may indeed help prevent fat accumulation in the liver linked to high cholesterol, reducing the risk of fatty liver disease.
9
Omega-3 EPA+DHA improves cholesterol
EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
9
Significant reduction in ischemic events
Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT.
We analyzed the effects of icosapent ethyl, a form of Omega 3 fish oil, on patients with high triglycerides and cardiovascular issues. The REDUCE-IT trial involved over 8,000 statin-treated patients and demonstrated that icosapent ethyl significantly reduced both the first and total ischemic events, which include serious heart conditions like heart attacks and strokes.
This means that those at risk saw meaningful benefits from this treatment. Overall, we found that icosapent ethyl could be a valuable option for improving heart health in patients struggling with high cholesterol and triglycerides.
References
Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16213614
Hirako S, Kim H, Iizuka Y, Matsumoto A. Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice. Biomed Res. 2024;45:33. doi:10.2220/biomedres.45.33
Mjaatveit M, Oldernes H, Gudbrandsen OA. Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis. Br J Nutr. 2024;131:606. doi:10.1017/S0007114523002118
Zhang C, Wang X, Sun S, Fu Y, Wu Y, et al. Fat-1 expression alleviates atherosclerosis in transgenic rabbits. J Cell Mol Med. 2022;26:1306. doi:10.1111/jcmm.17188
Sugimoto K, Hosomi R, Shimono T, Kanda S, Nishiyama T, et al. Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice. J Oleo Sci. 2021;70:965. doi:10.5650/jos.ess21032
Jaca A, Durão S, Harbron J. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. S Afr Med J. 2020;110:1158. doi:10.7196/SAMJ.2020.v110i12.14730
Trivedi K, Le V, Nelson JR. The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention. Postgrad Med. 2021;133:28. doi:10.1080/00325481.2020.1783937
Saito M, Ishida N, Yamada H, Ibi M, Hirose M. 8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice. Biol Pharm Bull. 2020;43:919. doi:10.1248/bpb.b20-00162
Llop-Talaveron J, Badía-Tahull M, Lozano-Andreu T, Rigo-Bonnin R, Virgili-Casas N, et al. Phytosterolemia and γ-glutamyl transferase in adults with parenteral nutrition: Fish versus vegetal lipids: A randomized clinical trial. Nutrition. 2020;70:110587. doi:10.1016/j.nut.2019.110587
Antona ME, Ramos C, Stranges A, Monteiro AF, Gonzales Chaves MM, et al. Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats. Arch Oral Biol. 2020;109:104553. doi:10.1016/j.archoralbio.2019.104553
Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, et al. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res. 2019;63:e1801157. doi:10.1002/mnfr.201801157
Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, et al. Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT. J Am Coll Cardiol. 2019;73:2791. doi:10.1016/j.jacc.2019.02.032
Preston Mason R. New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease. Curr Atheroscler Rep. 2019;21:2. doi:10.1007/s11883-019-0762-1
Vikøren LA, Drotningsvik A, Bergseth MT, Mjøs SA, Austgulen MH, et al. Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain -3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. Nutrients. 2018;10. doi:10.3390/nu10070840
Blom WAM, Koppenol WP, Hiemstra H, Stojakovic T, Scharnagl H, et al. A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. Eur J Nutr. 2019;58:1615. doi:10.1007/s00394-018-1706-1
Shen J, Rastogi R, Guan L, Li F, Du H, et al. Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis. Neurol Res. 2018;40:499. doi:10.1080/01616412.2018.1451290
Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
Chang Y, Xuan Y, Zhang R, Ding X, Zeng Q, et al. Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents. Animals (Basel). 2024;15. doi:10.3390/ani15010021
Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. doi:10.1039/d4fo04961f
Coelho-Júnior HJ, Álvarez-Bustos A, Picca A, Calvani R, Rodriguez-Mañas L, et al. Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults. Nutrients. 2024;16. doi:10.3390/nu16234087
Cabrita ARJ, Barroso C, Fontes-Sousa AP, Correia A, Teixeira L, et al. Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota. Front Vet Sci. 2024;11:1449141. doi:10.3389/fvets.2024.1449141
Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. doi:10.1038/s41598-024-73672-6
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
Zhang D, Wang Z, Guo S, Sun Y, Zhou D, et al. F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol. Exp Gerontol. 2024;196:112577. doi:10.1016/j.exger.2024.112577
Zhao W, Wang Y, Li J, Chen T, Yin D, et al. Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study. Lipids. 2024;59:145. doi:10.1002/lipd.12406
Li P, Khan S, Huang Y, Lu S, Zhou P, et al. Effect of Perilla seeds inclusion on the performance, egg quality characteristics, biochemical parameters and egg yolk fatty acid composition of laying hens. Trop Anim Health Prod. 2024;56:147. doi:10.1007/s11250-024-03983-3
Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. doi:10.3390/medicina60010075
Mueller PA, Bergstrom P, Rosario S, Heard M, Pamir N. Fish Oil Supplementation Modifies the Proteome, Lipidome, and Function of High-Density Lipoprotein: Findings from a Trial in Young Healthy Adults. J Nutr. 2024;154:1130. doi:10.1016/j.tjnut.2024.01.007